Mild cognitive impairment (MCI) can be the initial manifestation of autoimmune limbic encephalitis (ALE), a disorder that at\ntimes presents a diagnostic challenge. In addition to memory impairment, clinical features that might suggest this disorder include\npersonality changes, agitation, insomnia, alterations of consciousness, and seizures. Once recognized, ALE typically responds to\ntreatment with immune therapies, but long-term cognitive deficits may remain. We report two cases of patients with MCI who\nwere ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex. Months after apparent\nresolution of their encephalitides, both underwent neuropsychological testing, which demonstrated persistent cognitive deficits,\nprimarily in the domains of memory and executive function, for cases 1 and 2, respectively. A brief review of the literature is\nincluded.
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